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Clomiphene
Before prescribing clomiphene, your doctor may advise pelvic exams or ultrasounds to assess any problems with your ovaries or uterus.
The empiric use of clomiphene citrate raises that to 8-10% per month.
Sato, M., Glasebrook, A.L. and Bryant, H.U. 1994a ; Raloxifene: a selective estrogen receptor modulator. J. Bone Miner. Metab., 12, S9-S20. Sato, M., Kim, J., Short, L.L. et al. 1995 ; Longitudinal and cross-sectional analysis of raloxifene effects on tibiae from ovariectomized aged rats. J. Pharmacol. Exp. Ther., 272, 12521259. Sato, M., McClintock, C., Kim, J. et al. 1994b ; Dual-energy x-ray absorptiometry of raloxifene effects on the lumbar vertebrae and femora of ovariectomized rats. J. Bone Miner. Res., 9, 715724. Sato, M., Rippy, M.K. and Bryant, H.U. 1996 ; Raloxifene, tamoxifen, nafoxidine, or estrogen effects on reproductive and nonreproductive tissues in ovariectomized rats. FASEB J., 10, 905912. Scheele, W.H., Symanowski, S.M., Neale, S. et al. 1997 ; Raloxifene does not cause stimulatory effects on the uterus in healthy postmenopausal women. The Endocrine Society 79th Annual Meeting Program. Endocrine Society Press, Bethesda, USA, p. 498. Schering Corporation 1999 ; Fareston toremifine ; . In Physician's Desk Reference, 53rd ed. Medical Economics Company, Montvale, NJ, USA, pp. 28422843. Stenbygaard, L.E., Herrstedt, J., Thomsen, J.F. et al. 1993 ; Toremifene and tamoxifen in advanced breast cancer--a double-blind cross-over trial. Breast Cancer Res. Treat., 25, 5763. Stewart, H.J., Forrest, A.P., Everington, D. et al. 1996 ; Randomized comparison of 5 years of adjuvant tamoxifen with continuous therapy for operable breast cancer. The Scottish Cancer Trials Breast Group. Br. J. Cancer, 74, 297299. Stewart, P.J. and Stern, P.H. 1986 ; Effects of the antiestrogens tamoxifen and clomiphene on bone resorption in vitro. Endocrinology, 118, 125131. Swedish Breast Cancer Cooperative Group 1996 ; Randomized trial of two versus five years of adjuvant tamoxifen for postmenopausal early stage breast cancer. J. Natl Cancer Inst., 88, 15431549. Tarlatzis, B.C. and Grimbizis, G. 1998 ; Future use of clomiphene in ovarian stimulation. Will clomiphene persist in the 21st century? Hum. Reprod., 13, 23562358. Tomas, E., Kauppila, A., Blanco, G. et al. 1995 ; Comparison between the effects of tamoxifen and toremifene on the uterus in postmenopausal breast cancer patients. Gynecol. Oncol., 59, 261266. Tormey, D.C., Gray, R. and Falkson, H.C. 1996 ; Postchemotherapy adjuvant tamoxifen therapy beyond five years in patients with lymph node-positive breast cancer. Eastern Cooperative Oncology Group. J. Natl Cancer Inst., 88, 18281833. Turken, S., Siris, E., Seldin, D. et al. 1989 ; Effects of tamoxifen on spinal bone density in women with breast cancer. J. Natl Cancer Inst., 81, 1086 1088. Turner, R.T., Evans, G.L., Sluka, J.P. et al. 1998 ; Differential responses of estrogen target tissues in rats including bone to clomiphene, enclomiphene, and zuclomiphene. Endocrinology, 139, 37123720. Turner, C.H., Sato, M. and Bryant, H.U. 1994 ; Raloxifene preserves bone strength and bone mass in ovariectomized rats. Endocrinology, 135, 20012005. Veronesi, U., Maisonneuve, P., Costa, A. et al. 1998 ; Prevention of breast cancer with tamoxifen: preliminary findings from the Italian randomised trial among hysterectomised women. Italian Tamoxifen Prevention Study. Lancet, 352, 9397. Vogel, C.L., Shemano, I., Schoenfelder, J. et al. 1993 ; Multicenter phase II efficacy trial of toremifene in tamoxifen-refractory patients with advanced breast cancer. J. Clin. Oncol., 11, 345350. Wakeling, A.E. and Valcaccia, B. 1983 ; Antioestrogenic and antitumour activities of a series of non-steroidal antioestrogens. J. Endocrinol., 99, 455464. Wakeling, A.E., O'Connor, K.M. and Newboult, E. 1983 ; Comparison of the biological effects of tamoxifen and a new antioestrogen LY 117018 ; on the immature rat uterus. J. Endocrinol., 99, 447453. Wakeling, A.E., Valcaccia, B., Newboult, E. and Green, L.R. 1984 ; Nonsteroidal antioestrogens receptor binding and biological response in rat uterus, rat mammary carcinoma and human breast cancer cells. J. Steroid Biochem., 20, 111120. Walsh, B.W., Kuller, L.H., Wild, R.A. et al. 1997 ; The effect of raloxifene on markers of cardiovascular risk in healthy, post-menopausal women. Atherosclerosis, 134, 182. Walsh, B.W., Kuller, L.H., Wild, R.A. et al. 1998 ; Effects of raloxifene on serum lipids and coagulation factors in healthy postmenopausal women. J. Am. Med. Assoc., 279, 14451451. Ward, R.L., Morgan, G., Dalley, D. and Kelly, P.J. 1993 ; Tamoxifen reduces bone turnover and prevents lumbar spine and proximal femoral bone loss in early postmenopausal women. J. Bone Miner. Res., 22, 8794.
Et al., 1971; Schulz et al., 1972 ; . many other species clomiphene is to be mixed estrogen agonistis it is often stated that ZUC and ENC is antiestrogenic.
Clomiphene use
Intrathecal Drug Delivery: Evaluation and Results The patient was not a surgical candidate, and neurostimulation therapy was not indicated because of the nature and location of the pain. He had experienced no benefit in the past from oral narcotics, but did experience improved rest for one day when meperidine hydrochloride was administered intramuscularly. The possibility of intrathecal drug delivery was discussed with the patient.
Ovulation Induction Results from a randomized, assessor-blind, group comparative, multicenter safety and efficacy study of Follistim in 172 chronic anovulatory women who failed to ovulate and or conceive during clomiphene citrate treatment are summarized in Tables 3 and 4. Table 3. Cumulative Ovulation Rates and clozaril.
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| Clomiphene low testosteroneAny Other Business Weekly Scripts MU asked if there was anything that could be done about the volume of weekly scripts. CC said that they are required for adequate remuneration, but that some patients may be suitable for the future repeat dispensing scheme and clozapine, because clomiphene citrate 50mg tablets.
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Pregnancy and breast-feeding: do not use clomiphene if you are or become pregnant and mebeverine.
| Women who become pregnant after clomiphene therapy have an approximately 5% to 8% chance of multiple pregnancy.
160; similarly, there is no standard clomiphene citrate regimen for ovulation induction in in vitro fertilization programs to produce ova for fertilization and reintroduction and combivir.
This perspective differed greatly from the neuropsychopharmacological perspective. Most of the many hundred delegates, who attended this presentation, were nevertheless of the opinion that this view was of considerable interest. It could potentially be of relevance to the development of new insights into the mechanisms of psychiatric diseases, and thus possibly new treatments.
INCLUDED PAPERS REVERSE PUBLICATION ORDER ; Hughes et al 1996 ; unexplained infertility systematic review 1 RCTs relevant to clinical clomiphene citrate CC ; question alone and in combination with interuterine insemination IUI ; pregnancy per patient, pregnancy per treatment cycle initiated. Pregnancy defined by positive urine of serum aHCG, fetal heart on u s assessment, trophoblastic tissue on pathologic exam or live birth CC with without IUI vs placebo. Clomiphenf dose range of 50-250 mg used up to 10 days in the early follicular phase and lamivudine.
Zuclomiphene is inert and makes up about one third of the total medication.
Obstetric advice The following advice was obtained from independent obstetrician Dr Peter Dukes: "Thank you very much for asking me to review the claim of [Mr and Mrs A] with regard to their care at [the fertility clinic] and in particular by [Dr B], an employee of [the first fertility clinic]. As a couple [Mr and Mrs A] had had a fertility problem which was initially investigated by [Dr C] and he noted at the time that there was a degree of oligomenorrhoea with rather variable cycle lengths but, on ultrasound, no convincing evidence of polycystic ovary syndrome. In view of the irregularity of the cycles it was decided that Clomiphenne treatment should be started to induce regular ovulation, but the notes do not suggest to what extent this was carried out. [Mr and Mrs A] subsequently sought assistance from [the fertility clinic] and a referral note was forthcoming from [Mrs A's general practitioner] and [Dr C] forwarded his notes to [the fertility clinic] from her original consultations. [Mrs A] was initially seen at [the fertility clinic] on 7 June 2001 with 2 years of primary infertility. At this stage it was noted that she was fit and well but had previously been investigated for an eating disorder. Her height is 1.7 metres and her weight 75 kilograms with a BMI of 24. The irregularity of her cycles was again noted but, more particularly, in [Mr A's] investigations, he was found to be significantly oligospermic on two occasions. After a full work up on both [Mr and Mrs A] it was decided that the male factor was the main problem and it was felt that intracytoplasmic sperm injection ICSI ; would be the most appropriate management for their infertility. They were accepted as eligible for treatment on 30 November 2001. They were seen on 14 January 2002 by [Dr B] for orientation and it was decided that the treatment would start with the March cycle. In the event stimulation started on 16 May 2002. However, on 27 May [Mrs A] became unwell with breathlessness and pain and she phoned [the fertility clinic] but ultimately, because of her symptoms, took herself to [the second public hospital] where she was assessed and was transferred to [the ward at the first public hospital] after discussion with [Dr D]. During the stimulatory phase [Dr D] assessed her on 22 May by ultrasound and [Dr B] again on 26 May, the day prior to her admission with pain and zidovudine.
The prevalence of dementia dramatically increases during aging and represents a major health and socioeconomic problem that puts forward a serious strain on the optimism brought by the continuous increase in life expectancy observed in most industrial countries. Alzheimer disease AD ; , the most frequent cause of dementia in adults, is a heterogeneous disorder in terms of clinical presentation and neuropathology, and its diagnosis is difficult due to the absence of specific markers, the overlap of its morphological features with those observed in non-demented elderly individuals, and frequent comorbidity. During the last years, the quality and pattern of brain lesions in AD, their spreading along well-defined anatomical pathways and the consecutive biochemical changes have been described, and recent insights into the cell biology of the basic lesions - amyloid peptide and tau protein being two pivotal agents - are providing a better understanding of the underlying pathobiological process. However, many fundamental questions concerning the pathology of AD, its relations to clinical phenotypes and the lesion threshold for cognitive impairment are under discussion. The clinical diagnostic accuracy of probable AD using established criteria and modern neuroimaging and laboratory methods is 75-92%, with a sensitivity of 91% and a specificity of 55-84%. Although the histopathological criteria for AD are not fully established and undergo continuous revisions, the unequivocal diagnosis of AD and other dementing disorders still rests on histological brain examination, for example, clomiphene online.
There is a 1 chance approximately 6% ; that clomiphene therpay will result in multiple pregnancies in most cases these will be twins and compazine.
Female Sex Workers and Men having Sex with Men HIV AIDS and STI prevention programs supported by SHIP USAID Save the Children ; and GFATM targeting FSWs and MSM envisage outreach work, peer education, VCT and IEC. In addition, FSWs have free diagnostic & treatment services on HIV STIs at user friendly "Healthy Cabinets" in Tbilisi capital ; & 2 most affected regions Adjara & Samegrelo ; . Data on utilization of HIV prevention programmes are provided by Save the Children Federation from BSS reports USAID, SHIP project ; . In 2002 72.8% of FSWs reported participation in HIV prevention programs, including 73.9% of FSWs younger than 25 years and 71.9% of FSWs 25 years. By 2004 % of FSWs having benefited from HIV prevention programs has increased up to 75.6%, with proportion of FSWs younger than 25 years reached with prevention programs was increased substantially up to 86.5.
Disorders excluded by his answer is provided. For any such disorder the precise reason for exclusion is given, exposing the system's logic to the user see Fig. 5 ; . When thequestionnaire hasterminated, thesystem may list the disorders remaining and the facts that can advance the diagnosis see Fig. 6 ; . A distribution matrix indicates the status every remaining fact in each potenof tial disorder. The matrix, which includes the effect of all implications, specifies the differential diagnostic power of the undetermined facts. To continue the previous exwith ample, the decision was to check the patient's 1 7 K which were found to be less than 15; the physician entered fact - 2 9 as result two disorderswere excluded ; . The subsequent matrix showed a clomiphene test as differentially significant. The decision was made to perform the test, which yielded a positive response, and the corresponding fact 16 9 ; was entered, resulting in a final diagnosis of anovulation due to feedback disorder. This example is fairly representative of patient management in this area of endocrinology in the sense that diagnosis and treatment may well be intertwined. Thus the attempt to activate the hypothalamus with clomiphene not only serves to check thehypothesis of feedback disorder, but when successful is regarded as the therapy of choice. In other situations the selection of treatment constitutes the subsequent phase of system use whereby the indicated therapy is a function of specific patient data and the diagnosis made. In the example cited, the determination to check the level of 17 ketosteroids involved a special laboratory procedure. For purposes of illustration the results were entered directly. ; In the normal course of events, a date is scheduled to collect and test a urine sample from the patient. Thefindings are entered into the system and the physician re and prochlorperazine.
19. Kim LH, Taylor AE & Barbieri RL 2000 ; . Insulin sensitizers and polycystic ovary syndrome: can a diabetes medication treat infertility? Fertility and Sterility, 73: 1097-1098. 20. Nestler JE, Jakubowicz DJ, Evans WS & Pasquali R 1998 ; . Effects of metformin on spontaneous and clomiphene induced ovulation in the polycystic ovary syndrome. New England Journal of Medicine, 338: 1876-1880. 21. Nestler JE, Stovall D, Akhter N, Iuomo MJ & Jakubowicz DJ 2002 ; . Strategies for the use of insulin-sensitizing drugs to treat infertility in women with polycystic ovary syndrome. Fertility and Sterility, 77: 209-215. 22. Velazquez EM, Acosta A & Mendoza S 1997 ; . Menstrual cyclicity after metformin therapy in polycystic ovary syndrome. Obstetrics and Gynecology, 16: 392-395. 23. Glueck CJ, Phillips H, Cameron D, Sieve-Smith L & Wang P 2001 ; . Continuing metformin throughout pregnancy in women with polycystic ovary syndrome appears to safely reduce first trimester spontaneous abortion: a pilot study. Fertility and Sterility, 75: 46-52. 24. Jakubowicz DJ, Inorno MJ, Jakubowicz S, Roberts KA & Nestler JE 2002 ; . Effects of metformin on early pregnancy loss in the polycystic ovary syndrome. Journal of Clinical Endocrinology and Metabolism, 87: 524-529. 25. Heard MJ, Pierce A, Carson SA & Buster JE 2002 ; . Pregnancies following use of metformin for ovulation induction in patients with polycystic ovary syndrome. Fertility and Sterility, 77: 669-673. 26. Erickson GF, Magoffin D, Garzo VG, Cheung AP & Chang R 1992 ; . Granulosa cells of polycystic ovaries: Are they normal or abnormal? Human Reproduction, 7: 292-299. 27. Unger JW, Livingston JN & Moss 1991 ; . Insulin receptors in the central nervous system: localization, signaling mechanisms and functional aspects. Progress in Neurobiology, 36: 343-362. 28. Adashi EY, Hsueh AJW & Yen SSC 1981 ; . Insulin enhancement of luteinizing hormone and follicle-stimulating hormone release by cultured pituitary cells. Endocrinology, 108: 1441-1449.
Biggers, Brinster, Bavister, Chang, Daniels, Edwards, Hafez, Wales, Whitten, Whittingham, Yanagimachi Stimulation 1958 Gemzel & Burth Show urinary extracts from postmenopausal women induce ovulation 1961 Greenblatt Cllomiphene citrate is widely used 1960Clomiphene citrate and the early forms 1970s of urinary extracts increase in use 1980 Leyendecker Use of synthetic GnRH Highly purified urinary products, GnRH agonists and antagonists, synthetic and bio-engineered gonadotrophins Human ART 1955 Shettles Human oocytes and sperm cultured in fallopian tube scrapings, no fertilization 1965 Edwards Cultures immature human oocytes to maturity 1966 Edwards Reports lack of fertilization; medium appears to prevent fertilization of human oocytes 1968 Bavister Achieves IVF and cleavage of hamster oocytes 1968 Edwards Uses Bavister's media; achieves human IVF 1969 Edwards Introduces clinical human IVF, culture and ET Uses clomipheje and urinary product inductions Over 100 cycles performed, 1 ectopic pregnancy 1978 Edwards Tries again using a natural cycle on 3 women July 25, 1978 Louise Brown is born; 21 years later a British newspaper wrote: "Louise Brown, the world's first test-tube baby, is 21 today, and IVF, the medical miracle which gave her life, is now routine." Continued on next page and coreg and clomiphene.
Clomiphene citrate challenge testing
ABSTRACT Estrogen inhibits postmenopausal bone loss and decreases fracture risk. Unfortunately, estrogen replacement therapy has many undesirable side effects, the majority of which are due to stimulation of reproductive tissues. Tissue specific estrogen agonists provide a promising new alternative to natural estrogens for hormone replacement. Clomiphend CLO ; is a substituted triphenylethylene antiestrogen based on its ability to antagonize estrogen-mediated uterine growth in rodents. CLO is used clinically for the treatment of disorders of ovulation in patients wishing to become pregnant. In order to determine whether CLO has tissue selective actions, we performed a dose-response study in adult 6-month-old ; ovariectomized OVX'd ; rats. The rats received daily gavage ; doses of either 17 -ethynyl estradiol E ; 0.1 mg kg ; or CLO 0.0110 mg kg ; daily for 5 weeks. Long-term loss of ovarian function had no effect on serum cholesterol, greatly decreased uterine weight, cancellous bone area and trabecular number, and increased bone formation rate BFR ; and osteoblast and osteoclast perimeters. E treatment of OVX'd rats prevented uterine atrophy, greatly lowered cholesterol, and prevented many of the bone changes. CLO was a very weak estrogen agonist in supporting uterine weight, a partial agonist in reducing serum cholesterol, and an excellent agonist in maintaining normal bone mass and indices of bone turnover. We conclude from these studies that CLO exhibits pronounced tissue selective estrogen agonism in the rat. Specifically, CLO is effective in preventing cancellous bone loss in the OVX'd rats and has minimal uterotrophic activity. Endocrinology 138: 1794 1800.
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Ovulation Induction OI ; or Controlled Ovarian Stimulation COH ; IUI Cycles With this mode of treatment, the corpus luteum or lutea are generally intact. However, many of the patients who require this therapy are noted to have dysfunctional luteal phases during their natural cycles. In addition, supplementing progesterone during these cycles has been shown in studies to improve the ongoing pregnancy rates. Estrogen supplementation is usually not needed in these cycles unless there has been poor endometrial lining development noted during the stimulation monitoring. This is occasionally seen in cycles in which clomipnene citrate Clomid; Serophene ; has been administered. If so, than Estrace 2 mgm vaginally BID is administered starting mid cycle and is continued until the 8th week of pregnancy from the LMP. Progesterone is generally supplemented as Prometrium 200mg vaginally BID as or as Crinone vaginal applications BID until 8 weeks from the LMP. Prometrium is manufactured to be taken orally, but better absorption and fewer side effects have us prescribe it for vaginal administration.
Though there are now fewer discount drug cards than there were immediately preceding implementation of Medicare part D, there are still a number of them available, offered both through drug companies, independent companies as well as through the government see Ohio's Best Rx and Cuyahoga Meds-for-Less above ; . Be discerning in your choice to utilize any drug card, however, keeping in mind that many of these companies are for-profit and may not be solely motivated by charitable intentions. You may want to ask yourself some of the following questions from : rxassist faqs drug-discount-cards Eligibility: Is there an income limit? Do you qualify? ; Is there an age limit? Do you qualify? ; Do you have to be a member of an association to get this discount? Does the plan cover you alone, you and your spouse, or your entire family? Costs: Is this plan for medication only or is it part of health, vision and or dental coverage? Is there a membership enrollment annual fee? Is there a monthly fee? What are your co-payments? Are there additional shipping and handling fees? Will the money you save be more than the money you spend on enrollment fees, co-payments, and other fees? Benefits: Are drugs provided through a mail-order pharmacy or a walk-in pharmacy? Do you have to use a "participating pharmacy?" Are these convenient to you? ; Are the drugs you need covered by the plan? What drugs are not covered by the plan? Does the plan cover both generic and brand name drugs? Is the % discount the same for generic and brand name drugs? Is the discount off the retail price? Make sure the plan is really saving you money compared to what you would normally pay at your local pharmacy. ; Is there a limit on the benefits you can receive in a year? Protection: Does the plan make available detailed description of coverage? Make sure you get and read through all the written material regarding the discount card program ; Does the plan have a customer service number, preferably one that is toll-free? What are the options for canceling this card? What is the policy on refunding your fees?.
The clomiphene or letrozole cycle is outlined as below: clomiphene clomid, serophene ; is a drug that has been used for more than 50 years to stimulate follicular development.
Experienced career journalist who has previously served as an editor at The Washington Post and president of United Press International UPI ; . Medical Week News also relies on an advisory board of medical and journalist experts, including luminaries like Reese Schonfeld, co-founder and former president of the Cable News Network CNN ; . 15. On March 30, 2004, Mr. Benjamin registered the domain name, for instance, clomiphene side effects.
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Help - search - members - calendar full version: clomiphene metabolism mind and muscle forums supplements advanced whizzo dec 14 2006, i have yet to find any information regarding the metabolism pathways involved in the elimination of clomiphene.
Williams, J.K., Wagner, J.D., Li, Z. et al. 1997 ; Tamoxifen inhibits arterial accumulation of LDL degradation products and progression of coronary artery atherosclerosis in monkeys. Arterioscler. Thromb. Vasc. Biol., 17, 403408. Wolmark, N., Dignam, J. and Fisher, B. 1998 ; The addition of tamoxifen to lumpectomy and radiotherapy in the treatment of ductal carcinoma in situ DCIS ; : preliminary results of NSABP Protocol B-24. Breast Cancer Res. Treat., 21, 227. Young, R.L., Goldzieher, J.W., Chakraborty, P.K. et al. 1991 ; Qualitative differences in estrogenic antiestrogenic effects of clomiphene and zuclomiphene. Int. J. Fertil., 36, 291295.
Miles jan 17 2007, quote whizzo @ dec 14 2006, 09: i have yet to find any information regarding the metabolism pathways involved in the elimination of clomiphene.
Other measurements of quality of life and, if available, some measure of exercise tolerance should also be monitored, since with some patients, spirometric measurements do not improve with bronchodilator therapy but overall health status does improve.
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MARINA is a software developed to assist investigators in their fight against the distribution of child abuse images. It overviews, in read-only mode, the file systems of an investigated hard drive, searching for images and videos that have been referenced as child pornography by gendarmerie units, while preserving the original evidence. The current version of MARINA is based on the use of MD5 hash signatures: a mathematical function that does not permit to calculate the image back from the signature non-reversible ; . The database currently includes over 344.000 image signatures. This number has proven sufficient to detect the most common locations of child pornography, but will increase in the future with information from newer cases. The software presents itself in the form of a bootable Linux CDROM. The main features of this software are: - The simple search of images and videos; - The search and copy of images and videos the copy is done to a hard drive provided by the investigator - The copy of all images and videos to enhance the finding capacities afterwards - The copy of archive compressed ; files or those linked to the use of electronic mail; MARINA is currently available for all Gendarmerie units in France and will be deployed this year to Police Nationale the other national police force ; units as well, for example, clomiphene cycle.
Thousand Oaks, CA June 4 ; --Amgen agreed to acquire Ilypsa, a private company that develops nonabsorbed drugs for renal disorders, for $420 million. More.
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| Clomiphene periodsGonadotropins are prescribed if clomiphene fails to successfully induce ovulation.
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Iabetes mellitus is the most common endocrine disorder of humans characterised by metabolic abnormalities leading to long-term complications involving kidneys, gastrointestinal tract, nerves, and blood vessels, thereby causing profound morbidity and mortality. Various studies point towards an increased prevalence of gall bladder disease in diabetics.1-3 This has been attributed to cholecystomegaly and impaired gall bladder contraction, mainly due to autonomic neuropathy seen in diabetics. Though gall bladder stasis is the most necessary pre-requisite for gallstone formation, other risk factors include sex, genetic factors, obesity, parity, diet, drugs, hyperlipidaemia, and ileal resection.4 The present study was undertaken to compare gall bladder.
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